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What is the most effective antifungal medication? OTC Topical Antifungals OTC topical antifungal agents, including butenafine hydrochloride, clotrimazole, miconazole nitrate, terbinafine hydrochloride, and tolnaftate, are considered safe and effective for use in the treatment of mild-to-moderate fungal skin infections. Newton Krause seeks lotrisone
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